Question

Which type mutation will affect the largest number of proteins produced by an of organism?

Answer 1

Any mutation in DNA replication would affect the largest number of proteins of an organism.

Explanation:

The Central Dogma postulates that DNA holds the molecular information for the making of proteins.
This is translated into mRNA and then transcribed into amino acids that undergo structural changes to form proteins some of which are catalysts.
Fidelity from start to finish ensures that the correct proteins are formed.
If mutations were to take place in replication then an entirely different kind of information would be coded in the cell. This would lead to an entirely different set of proteins to be made.