How does the anti-inflammatory response affect a wound?
1 Answer
Inflammation is a body defence mechanism by which it produces necessary vascular as well as tissue changes to prevent entry of microorganisms and set tissue for healing.
A wound if not highly perfused with WBCs that is in case of an immunocompromised person,can open up ways for microorganisms to enter,and they can infect locally as well as distally.
As a result it will even interfere with normal healing process thereby increasing more chances for microorganisms to invade easily.
So,antiinflammatory response thus interferes with normal body response to mess up the natural procedure.
But on the other hand it is evidenced that in some person exaggerated inflammatory response leads to excessive tissue destruction and hypertrophied scar and keloid formation,which are harmful for the subject,in such case antiinflammatory substances like corticosteroids are given to decrease inflammation as a part of palliative care.As for example granulomatous swelling in brain in T.B which tends to compress surrounding structure,there corticosteroids are indicated.
Hence,inflammation is truly defined as DOUBLE EDGED SWORD because both absence as well as excessive presence of it is harmful. And then comes the role of antiinflammatory substances in the later case.
