What happens to homologous chromosomes during mitosis? Biology The Eukaryotic Cell Mitosis 1 Answer Al E. Oct 17, 2017 The homologs don't separate or cross over or interact in any other way in mitosis, as opposed to meiosis. They will simply undergo cellular division like any other chromosome will. In the daughter cells they will be identical to the parent cell. Answer link Related questions Why is mitosis necessary for living organisms? How is metaphase distinguished? How do cytokinesis and telophase differ? How do chromosomes divide during anaphase? How can mitosis be a form of asexual reproduction? How does mitosis conserve the chromosome number? How are mitosis and meiosis different? What is anaphase? What is mitosis? What are kinetochores made of? See all questions in Mitosis Impact of this question 10432 views around the world You can reuse this answer Creative Commons License