Your chain can be defined as follows:
f(x) = color(green)(cos) color(blue)(e^(color(red)(4x)))
color(white)(xxx)= cos e^(w(x)) color(white)(xxx) " where " w(x) = color(red)(4x)
color(white)(xxx)= cos v(w) color(white)(xxxiii) " where " v(w) = color(blue)(e^w)
color(white)(xxx)= u(v) color(white)(xxxxxxi) " where " u(v) = color(green)(cos(v))
Thus, to compute the derivative, you need to build the derivatives of w(x), v(w) and u(v):
w(x) = 4x color(white)(xxx) => color(white)(xx) w'(x) = 4
v(w) = e^w color(white)(xxx) => color(white)(xx) v'(w) = e^w = e^(4x)
u(v) = cos v color(white)(xx) => color(white)(xx) u'(v) = - sin v = - sin(e^w) = - sin(e^(4x))
Now, the only thing left to do is to multiply the three derivatives!
f'(x) = u'(v) * v'(w) * w'(x)
color(white)(xxxx) = - sin (e^(4x)) * e^(4x) * 4
color(white)(xxxx) = - 4 sin (e^(4x)) * e^(4x)