(16x^3 y)/(-4xy^3) *((-2xy)/(-x^-1))
(16x^3 y)/(-cancelcolor(red)((4x))y^3) *((cancel-cancelcolor(red)(2x)y)/(cancel-x^-1))
(cancel16x^3 y)/(-cancel2y^3) *(y)/(x^-1)
note: color(blue)(x^m/x^n = x^(m-n) and color(blue)(x^m.x^n = x^(m+n)
=(-8x^3 y^2)/((y^3.x^-1))
=-8 . x^(3+1) . y^(2-3)
=-8 . x^(4) . y^(-1)
=(-8 x^4) /y