By definition of derivative, F is differentiable in x_0 if the limit:
lim_(x->x_0) (F(x)-F(x_0))/(x-x_0)
exists.
Consider now any sequence {x_n} such that:
lim_(n->oo) x_n = x_0
note that:
F(x_n)-F(x_0) = int_a^(x_n) f(t)dt - int_a^(x_0) f(t)dt
and using the additivity of the integral:
F(x_n)-F(x_0) = int_(x_0)^(x_n) f(t)dt
Based on the mean value theorem, there must then be a point xi_n in (x_0,x_n) such that:
int_(x_0)^x f(t)dt =(x_n-x_0)f(xi_n)
so that:
(F(x_n)-F(x_0) )/(x_n-x_0) = f(xi_n)
Now, as xi_n in (x_0,x_n) and lim_n x_n = x_0 it follows that necessarily also:
lim_n xi_n = x_0
and as f(x) converges (really we need here ƒ(x) to be continuous) in x_0 then:
lim_n f(xi_n) = f(x_0)
and then:
lim_n (F(x_n)-F(x_0) )/(x_n-x_0) = f(x_0)
and because {x_n} is arbitrary:
lim_(x->x_0) (F(x)-F(x_0))/(x-x_0) = f(x_0)
which is basically the proof of the fundamental theorem of calculus.