First find the derivative of y=x^{tan(x)} by taking the natural log of both sides to get ln(y)=ln(x^{tan(x)})=tan(x)ln(x) and then differentiating with the Chain Rule (on the left) and Product Rule (on the right to get \frac{1}{y}\frac{dy}{dx}=sec^{2}(x)ln(x)+(tan(x))/x. Now multiply both sides by y=x^{tan(x)} to get dy/dx=x^{tan(x)}(sec^{2}(x)ln(x)+(tan(x))/x).
Now let z=cos(x^{tan(x)})=cos(y) and compute, with the Chain Rule,
dz/dx=-sin(y) dy/dx
=-sin(x^{tan(x)})x^{tan(x)}(sec^{2}(x)ln(x)+(tan(x))/x)